Regulation of alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP15, PTPN22, and RMND5A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of alpha-beta T cell differentiation activity versus PARP15 in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP15 →	+0.700	+0.685	.001	.001	3	7
UCEC	PTPN22 →	+0.717	+0.678	<.001	.002	3	6
GBM	RMND5A →	-0.458	-0.938	<.001	<.001	3	6
GBM	SCIMP →	+0.414	+0.802	<.001	<.001	3	6
GBM	LINC01147 →	+0.513	+0.673	<.001	<.001	3	6
UCEC	JAK3 →	+0.758	+0.628	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046637 vs PARP15 — HNSC

Explore this scatter interactively →