Regulation of alpha-beta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, MBTD1, and NMT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of alpha-beta T cell differentiation activity versus LGALS1 in LUNG_NSCLC_LUSC (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LGALS1 →	+6.047	+0.438	<.001	.004	3	7
BLOOD_Lymphoma	MBTD1 →	-0.742	-0.247	<.001	<.001	3	7
BLOOD_Lymphoma	NMT2 →	+1.311	+0.249	.001	<.001	3	7
BLOOD_Lymphoma	TRAF4 →	-1.077	-0.291	<.001	<.001	3	6
BLOOD_Myeloma	TFE3 →	+0.925	+0.276	.006	.005	3	6
BLOOD_Lymphoma	SLC35E4 →	+1.727	+0.251	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046637 vs LGALS1 — LUNG_NSCLC_LUSC

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