Negative regulation of alpha-beta T cell activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE2, GPNMB, and TLR7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell activation activity versus ADGRE2 in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADGRE2 →	+0.650	+0.355	<.001	<.001	3	5
OV	GPNMB →	+1.366	+0.273	<.001	.009	3	5
OV	TLR7 →	+1.120	+0.317	<.001	.003	3	5
GBM	LRP5 →	-0.768	-0.398	<.001	.006	3	5
GBM	LYN →	+0.532	+0.464	<.001	<.001	3	5
GBM	RMND5A →	-0.282	-0.374	.005	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046636 vs ADGRE2 — OV

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