Negative regulation of alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP62, KLF11, and DCDC2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUP62 grouped by Negative regulation of alpha-beta T cell activation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NUP62 →	+0.685	+1.184	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	KLF11 →	-1.141	-1.148	.009	.004	3	4
BLOOD_Leukemia	DCDC2B →	-0.090	-1.029	.004	.001	3	4
SOFT_TISSUE	EPN3 →	+1.255	+1.284	.009	.002	3	4
BLOOD_Leukemia	RPUSD2 →	+0.543	+1.400	.005	.002	2	4
OESOPHAGUS	FNDC11 →	-0.917	-1.007	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUP62 by Negative regulation of alpha-beta T cell activation activity — BLOOD_Leukemia

Explore this box plot interactively →