Negative regulation of alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, AGTPBP1, and CLPP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGAV grouped by Negative regulation of alpha-beta T cell activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ITGAV →	+0.410	+0.114	.009	<.001	3	6
SOFT_TISSUE	AGTPBP1 →	+0.186	+0.087	.006	<.001	3	5
CNS	CLPP →	-0.301	-0.109	.004	.001	3	5
LUNG_SCLC	SLC52A2 →	-0.204	-0.090	.008	.008	3	5
BONE	TRIM28 →	-0.372	-0.143	.001	<.001	3	5
BREAST	PCDHA6 →	-0.084	-0.057	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGAV by Negative regulation of alpha-beta T cell activation activity — CNS

Explore this box plot interactively →