Negative regulation of alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS3, OPTN, and S100A6, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell activation activity versus LGALS3 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LGALS3 →	+4.074	+0.103	<.001	<.001	3	13
BLOOD_Lymphoma	OPTN →	+2.417	+0.078	<.001	<.001	3	12
OVARY	S100A6 →	+4.265	+0.068	<.001	.005	2	13
BLOOD_Lymphoma	CD151 →	+2.032	+0.093	<.001	<.001	3	12
CNS	HLA-C →	+2.318	+0.103	<.001	<.001	3	12
SOFT_TISSUE	MVP →	+2.346	+0.090	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046636 vs LGALS3 — OVARY

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