Positive regulation of alpha-beta T cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL3, GFI1, and MAP4K1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell activation activity versus APOL3 in LSCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	APOL3 →	+1.223	+0.344	<.001	<.001	3	10
LSCC	GFI1 →	+0.913	+0.321	<.001	<.001	3	10
BRCA	MAP4K1 →	+0.916	+0.382	<.001	<.001	3	9
OV	RASAL3 →	+0.775	+0.753	.001	<.001	3	9
UCEC	GIMAP2 →	+1.119	+0.298	<.001	<.001	3	9
LSCC	GZMK →	+1.246	+0.317	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046635 vs APOL3 — LSCC

Explore this scatter interactively →