Positive regulation of alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIP3L, EXOSC8, and GALC, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BNIP3L grouped by Positive regulation of alpha-beta T cell activation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BNIP3L →	-1.870	-0.372	<.001	.003	3	3
BLOOD_Lymphoma	EXOSC8 →	+1.135	+0.254	.004	<.001	3	3
KIDNEY	GALC →	-1.408	-1.081	.005	.004	3	3
BREAST	CLEC2D →	-1.061	-0.770	.007	.002	3	3
CNS	CRTC1 →	+0.732	+0.951	.003	.007	3	3
CNS	IVNS1ABP →	+0.814	+0.849	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BNIP3L by Positive regulation of alpha-beta T cell activation activity — BLOOD_Lymphoma

Explore this box plot interactively →