Regulation of alpha-beta T cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPG, IL12RB1, and ARHGAP9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of alpha-beta T cell activation activity versus SIRPG in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SIRPG →	+1.105	+1.327	<.001	<.001	3	9
HNSC	IL12RB1 →	+0.907	+1.220	<.001	<.001	3	9
HNSC	ARHGAP9 →	+0.861	+1.321	<.001	<.001	3	9
HNSC	PYHIN1 →	+1.120	+1.364	<.001	<.001	3	9
OV	PARP15 →	+0.827	+0.831	<.001	<.001	3	9
HNSC	SLAMF6 →	+1.143	+1.311	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046634 vs SIRPG — HNSC

Explore this scatter interactively →