Regulation of alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G0S2, CLIC1, and PLAUR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, G0S2 grouped by Regulation of alpha-beta T cell activation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	G0S2 →	-4.752	-1.611	.001	<.001	3	5
OESOPHAGUS	CLIC1 →	-0.605	-0.700	.006	.009	3	5
SKIN	PLAUR →	-1.463	-0.567	<.001	.001	3	5
SKIN	NHS →	-0.911	-0.733	<.001	.001	3	5
KIDNEY	FUT4 →	-1.094	-1.513	.001	<.001	3	4
LARGE_INTESTINE	MGST3 →	-0.654	-0.747	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

G0S2 by Regulation of alpha-beta T cell activation activity — BONE

Explore this box plot interactively →