Regulation of alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIM, ATP8B3, and SLC35E4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of alpha-beta T cell activation activity versus VIM in LUNG_NSCLC_LUSC (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VIM →	+5.331	+0.285	.004	.003	3	7
LUNG_NSCLC_LUSC	ATP8B3 →	+2.193	+0.285	<.001	.003	3	7
BLOOD_Lymphoma	SLC35E4 →	+2.217	+0.322	<.001	<.001	3	7
BLOOD_Lymphoma	LGALS1 →	+5.070	+0.296	<.001	<.001	3	7
PANCREAS	MARVELD3 →	-2.035	-0.294	.002	.002	3	6
BREAST	PACSIN1 →	-1.897	-0.301	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046634 vs VIM — LUNG_NSCLC_LUSC

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