Alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, PARP15, and LILRB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-beta T cell differentiation activity versus ARHGAP9 in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP9 →	+0.952	+1.375	<.001	<.001	3	6
LSCC	PARP15 →	+0.769	+1.009	.004	.001	3	6
GBM	LILRB1 →	+0.573	+0.781	<.001	<.001	3	6
GBM	LILRB2 →	+0.838	+0.852	<.001	<.001	3	6
LUAD	PIK3CD-AS1 →	+0.302	+0.298	<.001	<.001	3	6
GBM	FMNL1 →	+0.718	+0.978	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046632 vs ARHGAP9 — GBM

Explore this scatter interactively →