Alpha-beta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Alpha-beta T cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX11, NME6, and PSMB6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX11 grouped by Alpha-beta T cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX11 →	-0.264	-0.093	.005	.001	3	5
LIVER	NME6 →	-0.225	-0.115	<.001	.006	3	5
BLOOD_Leukemia	PSMB6 →	-0.405	-0.058	<.001	.001	3	4
BREAST	SGTA →	-0.181	-0.078	<.001	<.001	3	4
BREAST	SUPV3L1 →	-0.301	-0.097	.005	.004	3	4
BREAST	EN2 →	+0.130	+0.089	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX11 by Alpha-beta T cell differentiation activity — BREAST

Explore this box plot interactively →