Alpha-beta T cell activation

Across TCGA patient cohorts, RNA activity of the Alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, FCER1G, and CYBB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-beta T cell activation activity versus TLR8 in CCRCC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TLR8 →	+0.848	+1.105	<.001	.001	3	5
BRCA	FCER1G →	+0.887	+1.148	<.001	<.001	3	5
OV	CYBB →	+1.176	+0.619	.002	.006	3	5
CCRCC	SNX20 →	+0.858	+1.204	<.001	<.001	3	5
CCRCC	FCGR3A →	+0.907	+1.184	<.001	<.001	3	5
BRCA	HCK →	+1.085	+0.965	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046631 vs TLR8 — CCRCC

Explore this scatter interactively →