Alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Alpha-beta T cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR5, STRN4, and DDX58, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLR5 grouped by Alpha-beta T cell activation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TLR5 →	+0.178	+0.076	.005	.007	3	7
SOFT_TISSUE	STRN4 →	-0.395	-0.122	<.001	<.001	3	6
CNS	DDX58 →	+0.300	+0.091	.004	.003	3	5
BREAST	ZNF250 →	-0.507	-0.141	<.001	<.001	3	5
LUNG_SCLC	TRRAP →	-0.503	-0.112	.001	<.001	3	5
BLOOD_Lymphoma	KRT25 →	+0.375	+0.124	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLR5 by Alpha-beta T cell activation activity — KIDNEY

Explore this box plot interactively →