Alpha-beta T cell activation

Across TCGA cell cohorts, RNA activity of the Alpha-beta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAHD1, UQCRC1, and CIAO2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-beta T cell activation activity versus FAHD1 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAHD1 →	+0.841	+0.283	.001	.006	3	7
OVARY	UQCRC1 →	+1.001	+0.450	.001	.009	3	6
OVARY	CIAO2B →	+1.011	+0.469	.002	.004	3	6
OVARY	JUP →	-2.236	-0.575	.007	<.001	3	6
CNS	TANGO6 →	+0.565	+0.310	.003	.003	3	6
BLOOD_Myeloma	PREX1 →	+2.353	+0.234	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046631 vs FAHD1 — STOMACH

Explore this scatter interactively →