Gamma-delta T cell activation

Across TCGA patient cohorts, RNA activity of the Gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICOS, CYTH4, and CD40LG, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell activation activity versus ICOS in DLBC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ICOS →	+2.194	+0.095	<.001	<.001	3	34
SCLC	CYTH4 →	+1.870	+0.159	<.001	<.001	3	33
DLBC	CD40LG →	+1.828	+0.068	<.001	<.001	3	33
THYM	TNFSF8 →	+1.449	+0.083	<.001	<.001	3	33
SCLC	PTPN22 →	+2.182	+0.132	<.001	<.001	3	33
SKCM	GPR65 →	+1.495	+0.089	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046629 vs ICOS — DLBC

Explore this scatter interactively →