Gamma-delta T cell activation

Across TCGA patient cohorts, RNA activity of the Gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAJ42, ITGB7, and DOK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell activation activity versus TRAJ42 in LSCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAJ42 →	+1.040	+0.583	.001	.005	3	4
HNSC	ITGB7 →	+0.663	+0.611	.005	.005	3	4
HNSC	DOK3 →	+0.461	+0.614	.001	<.001	3	4
LSCC	TIFAB →	+0.331	+0.537	.001	.007	3	4
PDAC	NOTCH2P1 →	+0.119	+0.436	<.001	.007	3	3
GBM	UCN2 →	+1.041	+0.539	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046629 vs TRAJ42 — LSCC

Explore this scatter interactively →