Gamma-delta T cell activation

Across TCGA patient cohorts, RNA activity of the Gamma-delta T cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DIP2C_T264, HACL1_S192, and HSP90AA1_S595, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell activation activity versus DIP2C_T264 in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DIP2C_T264 →	-0.951	-0.892	<.001	<.001	3	3
GBM	HACL1_S192 →	-0.655	-0.672	<.001	.007	3	3
COAD	HSP90AA1_S595 →	-0.660	-1.249	<.001	<.001	3	3
LSCC	LAT_S84 →	+0.677	+0.985	<.001	<.001	3	3
PDAC	RRBP1_S959 →	+0.640	+0.699	<.001	.001	3	3
PDAC	TMED5 →	+0.453	+0.547	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046629 vs DIP2C_T264 — LSCC

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