Gamma-delta T cell activation

Across TCGA cell cohorts, RNA activity of the Gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf68, LZTS3, and JMJD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2orf68 grouped by Gamma-delta T cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C2orf68 →	+0.865	+1.328	.003	<.001	3	4
BREAST	LZTS3 →	-1.089	-0.862	.005	.002	3	4
CNS	JMJD4 →	+0.490	+1.172	.004	<.001	3	3
PANCREAS	SLC27A3 →	+1.442	+1.250	.007	<.001	3	3
PANCREAS	ZC3H11B →	+0.120	+1.130	.004	.002	3	3
PANCREAS	SRGAP2 →	+0.632	+1.099	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2orf68 by Gamma-delta T cell activation activity — STOMACH

Explore this box plot interactively →