Gamma-delta T cell activation

Across TCGA cell cohorts, RNA activity of the Gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAWR, FAAP100, and GMEB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-delta T cell activation activity versus PAWR in OESOPHAGUS (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PAWR →	-2.359	-1.871	.008	<.001	3	3
OESOPHAGUS	FAAP100 →	-1.303	-2.013	.006	<.001	3	3
PANCREAS	GMEB2 →	-0.523	-1.816	.009	.001	3	3
PANCREAS	GPR89A →	-0.474	-1.769	.006	<.001	3	3
PANCREAS	AUH →	-0.936	-1.769	.002	<.001	3	3
LIVER	NECAB1 →	+1.100	+1.839	.009	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046629 vs PAWR — OESOPHAGUS

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