Positive regulation of organ growth

Across TCGA patient cohorts, RNA activity of the Positive regulation of organ growth pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, DNAJC7, and RPL5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of organ growth activity versus TLN2 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TLN2 →	+0.426	+0.050	.001	.001	3	10
GBM	DNAJC7 →	-0.244	-0.047	<.001	<.001	3	10
LUAD	RPL5 →	-0.124	-0.033	.002	<.001	3	8
UCEC	TLN2_T1843 →	+0.680	+0.092	<.001	<.001	3	8
BRCA	TNS2_S102 →	+0.737	+0.029	<.001	<.001	3	8
UCEC	CAVIN1 →	+0.838	+0.077	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046622 vs TLN2 — HNSC

Explore this scatter interactively →