Positive regulation of organ growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of organ growth pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, VAC14, and ZBTB18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of organ growth activity versus BASP1 in LUNG_NSCLC_LUAD (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BASP1 →	+3.481	+1.087	<.001	<.001	3	7
STOMACH	VAC14 →	+0.990	+1.460	.003	<.001	3	5
LIVER	ZBTB18 →	+2.280	+1.727	.004	<.001	3	5
LARGE_INTESTINE	PCGF2 →	+0.619	+0.900	.002	.001	3	5
BREAST	ACD →	+0.715	+0.778	.003	.005	3	4
BREAST	POT1 →	+0.601	+0.921	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046622 vs BASP1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →