Negative regulation of organ growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of organ growth pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA1, NCL_T121, and SERPING1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organ growth activity versus SERPINA1 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINA1 →	+0.395	+0.027	.006	<.001	3	6
UCEC	NCL_T121 →	-0.816	-0.037	.001	.001	3	5
CCRCC	SERPING1 →	+0.588	+0.040	<.001	<.001	3	5
BRCA	VCL →	+0.290	+0.025	.001	.001	3	5
CCRCC	VCL_S579 →	+0.628	+0.033	.001	.001	3	5
BRCA	VIM →	+0.470	+0.030	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046621 vs SERPINA1 — BRCA

Explore this scatter interactively →