Negative regulation of organ growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of organ growth pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-16P, HMGN2P6, and STRA6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organ growth activity versus RNU6-16P in BRCA (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-16P →	-0.570	-0.540	.001	.001	3	3
LUAD	HMGN2P6 →	+0.190	+0.503	<.001	.001	3	3
BRCA	STRA6 →	-0.445	-0.482	.005	<.001	3	2
BRCA	NDUFB11 →	-0.321	-0.708	.001	<.001	3	2
BRCA	ACTG1P25 →	-0.257	-0.491	.004	<.001	3	2
BRCA	RNU2-13P →	+0.757	+0.560	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046621 vs RNU6-16P — BRCA

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