Negative regulation of organ growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of organ growth pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, HNRNPA1, and ABCC3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organ growth activity versus G6PD in OESOPHAGUS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	G6PD →	+2.225	+0.365	<.001	<.001	3	14
OVARY	HNRNPA1 →	-0.896	-0.561	.001	.008	3	7
LUNG_NSCLC_LUAD	ABCC3 →	+2.719	+0.343	<.001	<.001	3	6
LARGE_INTESTINE	PIAS2 →	-0.970	-0.244	.001	<.001	3	6
BLOOD_Leukemia	POLR1E →	-0.372	-0.244	.001	.004	3	5
LIVER	TRIM16 →	+3.115	+0.426	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046621 vs G6PD — OESOPHAGUS

Explore this scatter interactively →