Regulation of organ growth

Across TCGA patient cohorts, RNA activity of the Regulation of organ growth pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, PHLDB1_S324, and FGF2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organ growth activity versus TLN2 in UCEC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLN2 →	+0.585	+0.064	<.001	<.001	3	8
BRCA	PHLDB1_S324 →	+0.823	+0.026	.001	<.001	3	7
BRCA	FGF2 →	+0.799	+0.030	<.001	<.001	3	7
LSCC	FMNL3 →	+0.373	+0.044	<.001	<.001	3	7
BRCA	HSPA12B →	+0.456	+0.019	.001	.001	3	7
UCEC	QKI →	+0.312	+0.044	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046620 vs TLN2 — UCEC

Explore this scatter interactively →