Regulation of organ growth

Across TCGA cell cohorts, RNA activity of the Regulation of organ growth pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCYOX1L, TCP1, and CDC37L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCYOX1L grouped by Regulation of organ growth-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PCYOX1L →	-1.413	-0.300	.005	.003	3	3
LUNG_SCLC	TCP1 →	-0.790	-0.324	.002	.002	3	3
UPPER_AERODIGESTIVE_TRACT	CDC37L1 →	+0.953	+0.208	.004	.006	3	3
UPPER_AERODIGESTIVE_TRACT	UBE2R2 →	+0.982	+0.225	<.001	.002	3	3
LARGE_INTESTINE	AMD1 →	-0.629	-0.141	.009	.001	3	3
LARGE_INTESTINE	ECM1 →	+1.149	+0.133	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCYOX1L by Regulation of organ growth activity — STOMACH

Explore this box plot interactively →