Regulation of organ growth

Across TCGA cell cohorts, RNA activity of the Regulation of organ growth pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT2, TOR2A, and DDX23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organ growth activity versus CPT2 in KIDNEY (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CPT2 →	-1.027	-0.416	<.001	.001	3	3
KIDNEY	TOR2A →	-1.140	-0.309	<.001	.001	3	3
KIDNEY	DDX23 →	-0.926	-0.330	.004	.002	3	3
PANCREAS	ELK3 →	-1.392	-0.385	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ENC1 →	-1.270	-0.223	<.001	.001	3	3
LUNG_NSCLC_LUAD	JMJD1C →	-0.492	-0.219	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046620 vs CPT2 — KIDNEY

Explore this scatter interactively →