Regulation of centrosome cycle

Across TCGA cell cohorts, RNA activity of the Regulation of centrosome cycle pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHMP2B, CHMP1A, and VPS4B, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centrosome cycle activity versus CHMP2B in OESOPHAGUS (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CHMP2B →	+1.813	+0.188	.003	.001	3	13
LUNG_NSCLC_LUAD	CHMP1A →	+0.848	+0.186	<.001	<.001	3	11
LUNG_NSCLC_LUAD	VPS4B →	+1.033	+0.226	<.001	<.001	3	11
LUNG_SCLC	CHMP1B →	+1.152	+0.177	.001	<.001	2	11
LARGE_INTESTINE	MTPN →	+1.745	+0.270	<.001	<.001	3	10
OVARY	APRT →	+1.440	+0.225	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046605 vs CHMP2B — OESOPHAGUS

Explore this scatter interactively →