Regulation of mitotic centrosome separation

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic centrosome separation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC6, COPS3, and OR11H7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic centrosome separation activity versus H2BC6 in LUNG_NSCLC_LUAD (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H2BC6 →	-0.542	-1.410	.006	.004	3	3
LARGE_INTESTINE	COPS3 →	+0.533	+1.195	.009	<.001	3	3
OESOPHAGUS	OR11H7 →	-1.270	-1.796	<.001	<.001	3	3
BLOOD_Myeloma	YEATS2 →	+0.918	+0.230	<.001	.006	3	3
BLOOD_Myeloma	CHMP2B →	+0.781	+0.227	.006	.007	3	3
BLOOD_Leukemia	CDCA5 →	+0.583	+0.358	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046602 vs H2BC6 — LUNG_NSCLC_LUAD

Explore this scatter interactively →