Positive regulation of centriole replication

Across TCGA cell cohorts, RNA activity of the Positive regulation of centriole replication pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNA13, RASSF3, and HAUS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of centriole replication activity versus GNA13 in SKIN (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GNA13 →	+0.537	+0.800	.001	.007	3	4
URINARY_TRACT	RASSF3 →	+0.434	+0.420	.008	.008	3	4
BREAST	HAUS1 →	+1.188	+1.351	<.001	<.001	3	4
OESOPHAGUS	ZNF836 →	+0.834	+1.234	<.001	<.001	3	4
BLOOD_Leukemia	ZNF808 →	+0.665	+0.510	.004	.005	3	4
LUNG_NSCLC_LUSC	ADCK1 →	+1.249	+1.565	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046601 vs GNA13 — SKIN

Explore this scatter interactively →