Negative regulation of centriole replication

Across TCGA patient cohorts, RNA activity of the Negative regulation of centriole replication pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYP, SGF29, and TNRC6B_S567, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of centriole replication activity versus SYP in COAD (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SYP →	-0.858	-1.009	<.001	<.001	2	4
BRCA	SGF29 →	+0.196	+0.551	<.001	.001	3	3
LSCC	TNRC6B_S567 →	+1.493	+0.549	.007	<.001	2	4
OV	MPDZ_S354 →	-0.712	-0.866	<.001	<.001	3	3
LSCC	YEATS2_S447 →	+0.347	+0.347	.003	.002	2	3
COAD	CD79A_S215 →	-0.570	-1.125	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046600 vs SYP — COAD

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