Negative regulation of centriole replication

Across TCGA cell cohorts, RNA activity of the Negative regulation of centriole replication pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM37, BTN2A1, and FAM98A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM37 grouped by Negative regulation of centriole replication-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRIM37 →	-0.196	-1.045	.008	.003	3	8
STOMACH	BTN2A1 →	+0.143	+0.295	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	FAM98A →	+0.220	+0.325	.001	.008	3	3
LUNG_SCLC	GALT →	+0.207	+0.276	.001	.001	3	3
SKIN	MED9 →	-0.173	-0.449	.004	.008	3	3
CNS	KMO →	+0.175	+0.780	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM37 by Negative regulation of centriole replication activity — CNS

Explore this box plot interactively →