Negative regulation of centriole replication

Across TCGA cell cohorts, RNA activity of the Negative regulation of centriole replication pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are WYE-125132, PARP_9495, and I-BET-151, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WYE-125132 grouped by Negative regulation of centriole replication-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WYE-125132 →	-0.529	-0.300	.007	.019	3	2
BLOOD_Leukemia	PARP_9495 →	+1.085	+0.304	.002	.001	3	2
BONE	I-BET-151 →	+1.203	+0.326	.007	.024	3	2
BONE	AZD3514 →	+0.528	+0.326	.010	.024	3	2
BONE	I-CBP112 →	+0.383	+0.326	<.001	.024	3	2
SKIN	Nilotinib →	-1.133	-0.342	<.001	.013	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WYE-125132 by Negative regulation of centriole replication activity — SKIN

Explore this box plot interactively →