Negative regulation of viral entry into host cell

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral entry into host cell pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, C1S, and ZNF638, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral entry into host cell activity versus C1R in OV (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1R →	+0.812	+0.261	<.001	<.001	3	6
OV	C1S →	+0.661	+0.244	<.001	<.001	3	6
LSCC	ZNF638 →	-0.214	-0.159	<.001	<.001	3	5
COAD	DPY30 →	-0.616	-0.249	<.001	<.001	2	6
OV	EP300_S1038 →	-1.015	-0.212	.002	.002	3	5
PDAC	RARRES2 →	+0.734	+0.193	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046597 vs C1R — OV

Explore this scatter interactively →