Negative regulation of viral entry into host cell

Across TCGA cell cohorts, RNA activity of the Negative regulation of viral entry into host cell pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, STX11, and EPB41, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A4 grouped by Negative regulation of viral entry into host cell-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC25A4 →	-0.983	-1.100	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	STX11 →	+0.844	+0.906	.009	.004	3	3
UPPER_AERODIGESTIVE_TRACT	EPB41 →	+0.859	+0.876	.001	.006	3	3
OESOPHAGUS	ARL4C →	-1.294	-0.897	.003	.004	3	3
LUNG_NSCLC_LUAD	ZNF597 →	+0.598	+1.132	.006	<.001	3	3
LARGE_INTESTINE	UFSP1 →	-0.577	-0.858	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A4 by Negative regulation of viral entry into host cell activity — PANCREAS

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