Retinal cone cell development

Across TCGA patient cohorts, RNA activity of the Retinal cone cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF280C, NPEPL1, and PARP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal cone cell development activity versus ZNF280C in BRCA (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF280C →	-0.516	-0.054	<.001	<.001	3	5
GBM	NPEPL1 →	+0.488	+0.098	.001	<.001	3	4
BRCA	PARP1 →	-0.288	-0.044	.009	.002	3	4
UCEC	PLCD3_S496 →	+0.794	+0.069	.001	.006	2	5
OV	RPL12_S38 →	-0.758	-0.039	.003	.008	3	3
GBM	S100A13 →	+0.584	+0.075	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046549 vs ZNF280C — BRCA

Explore this scatter interactively →