Retinal cone cell development

pathway activity — cross-omics
GO:0046549Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Retinal cone cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAT1, GAL3ST1, and PLEKHA6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCANAT1 →+4.246+1.078.009.00634
CCRCCGAL3ST1 →+0.755+0.148.006<.00134
GBMPLEKHA6 →+0.787+0.602.001.00434
GBMRBMS1 →-0.449-0.501<.001.00134
GBMDMTN →+1.220+0.703<.001.00134
CCRCCCDS1 →+0.663+0.161.006<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration