Retinal cone cell development

Across TCGA cell cohorts, RNA activity of the Retinal cone cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN32, HSPB1, and TNFRSF10D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN32 grouped by Retinal cone cell development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN32 →	+0.101	+1.301	.007	.009	3	4
UPPER_AERODIGESTIVE_TRACT	HSPB1 →	-0.111	-0.111	.007	.007	3	4
STOMACH	TNFRSF10D →	-0.183	-1.488	<.001	<.001	3	4
LARGE_INTESTINE	HNF4A →	+0.237	+1.509	.007	<.001	3	4
LIVER	KCNJ1 →	+0.166	+1.502	.003	.005	2	4
LIVER	ARHGEF38 →	-0.238	-2.143	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN32 by Retinal cone cell development activity — PANCREAS

Explore this box plot interactively →