Retinal rod cell development

Across TCGA patient cohorts, RNA activity of the Retinal rod cell development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSBG1, GSTA3, and TGFBR3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal rod cell development activity versus ACSBG1 in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACSBG1 →	+0.172	+0.713	.005	.003	3	4
HNSC	GSTA3 →	+0.864	+0.474	.001	.002	3	4
HNSC	TGFBR3 →	+1.462	+0.704	<.001	<.001	3	4
GBM	SPNS3 →	+0.471	+0.405	.001	.009	3	3
GBM	DLEC1 →	+0.657	+0.431	.003	.007	3	3
LSCC	DNAH3 →	+0.815	+0.597	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046548 vs ACSBG1 — LSCC

Explore this scatter interactively →