Retinal rod cell development

Across TCGA cell cohorts, RNA activity of the Retinal rod cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL5, FAN1, and CCDC137, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL5 grouped by Retinal rod cell development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	METTL5 →	+0.695	+1.364	<.001	.001	3	5
LUNG_SCLC	FAN1 →	-1.058	-1.256	.001	.009	3	5
OVARY	CCDC137 →	-0.568	-0.845	<.001	.004	3	5
LUNG_SCLC	UNK →	-1.152	-1.453	<.001	<.001	3	4
LUNG_SCLC	IGF2BP2 →	+3.276	+1.665	.003	<.001	3	4
STOMACH	NR3C2 →	+1.125	+1.398	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL5 by Retinal rod cell development activity — LUNG_SCLC

Explore this box plot interactively →