Saliva secretion

Across TCGA patient cohorts, RNA activity of the Saliva secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1, DOCK9, and AQP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Saliva secretion activity versus TNKS1BP1 in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNKS1BP1 →	+0.282	+0.146	.001	<.001	3	5
PDAC	DOCK9 →	+0.261	+0.112	<.001	<.001	3	5
PDAC	AQP5 →	+0.903	+0.102	.001	.001	3	5
LSCC	FHL2 →	+0.665	+0.144	<.001	<.001	3	5
LSCC	KRT23 →	+1.385	+0.122	<.001	.008	3	5
UCEC	ARFIP1 →	+0.282	+0.159	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046541 vs TNKS1BP1 — LSCC

Explore this scatter interactively →