Saliva secretion

Across TCGA patient cohorts, RNA activity of the Saliva secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARFGEF3, AQP5, and ARRB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Saliva secretion activity versus ARFGEF3 in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARFGEF3 →	+0.997	+0.452	<.001	.002	3	4
OV	AQP5 →	+3.941	+0.388	<.001	<.001	3	4
GBM	ARRB1 →	+0.778	+0.632	<.001	<.001	3	3
HNSC	AZGP1 →	+1.368	+0.243	.002	.002	3	3
GBM	SLC26A8 →	+0.233	+0.514	<.001	.001	3	3
LSCC	TMEM125 →	+0.884	+0.736	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046541 vs ARFGEF3 — GBM

Explore this scatter interactively →