Saliva secretion

Across TCGA cell cohorts, RNA activity of the Saliva secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMIZ2, MTA1, and SEPTIN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMIZ2 grouped by Saliva secretion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZMIZ2 →	-0.964	-1.192	.001	.008	3	4
BLOOD_Leukemia	MTA1 →	-0.646	-1.458	.001	<.001	3	4
SOFT_TISSUE	SEPTIN6 →	-1.659	-1.212	.007	.006	3	4
BLOOD_Leukemia	SLTM →	-0.814	-1.378	.001	.002	3	3
SOFT_TISSUE	TBCK →	-0.956	-1.419	.001	.003	3	3
LUNG_NSCLC_LUAD	CENATAC →	-0.875	-0.757	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMIZ2 by Saliva secretion activity — BLOOD_Leukemia

Explore this box plot interactively →