Saliva secretion

Across TCGA cell cohorts, RNA activity of the Saliva secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF6, USP3, and FDX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF6 grouped by Saliva secretion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAPGEF6 →	-0.300	-0.295	.001	<.001	3	5
PANCREAS	USP3 →	-0.148	-0.148	.006	.002	3	4
LUNG_NSCLC_LUSC	FDX2 →	+0.354	+1.945	.006	.005	3	3
SOFT_TISSUE	A4GNT →	+0.246	+1.931	.009	<.001	3	3
SOFT_TISSUE	IL13RA2 →	+0.296	+1.903	<.001	.003	3	3
KIDNEY	EPHA4 →	+0.195	+0.153	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF6 by Saliva secretion activity — LIVER

Explore this box plot interactively →