Negative regulation of photoreceptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of photoreceptor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, EPHB3, and SOX6_S411, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of photoreceptor cell differentiation activity versus SOX9 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOX9 →	+0.913	+0.165	<.001	<.001	3	6
UCEC	EPHB3 →	+0.776	+0.125	.001	.001	3	5
GBM	SOX6_S411 →	+0.629	+0.116	<.001	<.001	3	5
BRCA	RPP40 →	+0.262	+0.098	<.001	.002	3	4
BRCA	SOX6_S454 →	+1.489	+0.166	<.001	<.001	3	4
BRCA	NUCB2 →	-0.565	-0.133	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046533 vs SOX9 — LSCC

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