Negative regulation of photoreceptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, GAPDHP62, and MORC2-AS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of photoreceptor cell differentiation activity versus SOX9 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOX9 →	+1.604	+0.960	.001	.002	3	7
GBM	GAPDHP62 →	+0.233	+0.672	.003	.004	3	5
HNSC	MORC2-AS1 →	+0.452	+0.193	.001	.005	3	4
GBM	SETD6 →	+0.330	+0.726	.005	.002	3	4
GBM	PROX2 →	+0.632	+0.928	<.001	<.001	3	4
COAD	GID8 →	+0.694	+0.239	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046533 vs SOX9 — BRCA

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