Negative regulation of photoreceptor cell differentiation

pathway activity — cross-omics
GO:0046533Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of photoreceptor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX8, SIN3B_S740, and SIPA1_S839, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSOX8 →+3.121+1.267<.001<.00134
LUADSIN3B_S740 →+0.569+0.985<.001<.00133
LUADSIPA1_S839 →-0.651-1.159<.001<.00133
UCECTYK2_Y292 →-0.806-1.702<.001<.00133
LUADC16orf86_S114 →-0.864-1.010.002<.00133
GBMEPB41_S709 →-0.596-1.070<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration