Negative regulation of photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCOR3, RPS26, and FAM167B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCOR3 grouped by Negative regulation of photoreceptor cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RCOR3 →	+0.818	+1.557	.003	.003	3	4
URINARY_TRACT	RPS26 →	-0.869	-1.557	.009	.003	3	4
SKIN	FAM167B →	-1.766	-0.747	.003	.004	3	4
LARGE_INTESTINE	COBL →	+1.387	+0.854	.004	.002	3	4
STOMACH	C20orf194 →	-1.738	-1.127	.004	.003	3	4
SOFT_TISSUE	TMEM231 →	-1.348	-1.470	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCOR3 by Negative regulation of photoreceptor cell differentiation activity — URINARY_TRACT

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